A new Coronavirus, SARS-CoV2, can trigger brain inflammation of the skin
Worldwide have been infected, more than 1.6 million people with the Coronavirus Sars-CoV-2. Tens of thousands have died of or with lung disease COVID-19, the the pathogen triggers. The new Virus, according to new findings, but also life-threatening brain inflammation skin cause.
In the subject of media reports for several days, via a neural route of transmission of SARS-CoV2, which has been accepted as very likely and the neurological symptoms of many COVID-19-Concerned could explain. A case report provides the proof, reported the German society of neurology e. V. (DGN) in the current message.
Neurological complaints in COVID-19
Still, the number of infections with the new Coronavirus, SARS-CoV2 is on the rise. Not all people infected with the pathogen, show symptoms.
In some patients mild symptoms only occur, however, it comes to severe cases of COVID-19.
In the recent past, Researchers have also frequently neurological complaints at COVID-19 discovered.
In a case report from Japan that was published in the journal “International Journal of Infectious Diseases”, it was revealed that a young man, skin a by the new pathogen-triggered brain – and brain inflammation suffered. According to the DGN has been demonstrated in the nervous water of SARS-CoV-2 RNA, the nasopharyngeal swab was negative.
Corona viruses can penetrate into the brain
As the communication explained, we know from recent publications that SARS-CoV-2 can penetrate, such as the already well-known corona viruses SARS and MERS in the Central nervous system (CNS) or in the brain, in particular in the brain stem.
This could explain, to occur why COVID-19 diseases in addition to the typical signs of the disease are fever, sore throat and cough-by the way, in some cases, even without respiratory symptoms, neurological symptoms such as loss of sense of taste and smell, headache, fatigue, Nausea, vomiting and disturbances of consciousness.
Special attention in the above case example from Japan, in the case of the SARS-CoV-2 in the case of a young man with a brain skin inflammation (Meningitis) has triggered excited now.
“As is to be expected after the experience with SARS, and MERS has all the features of casuistry impressive that the nervous system COVID-19-diseases can be infected, even in very young patients,” explains Professor Peter Berlit, Essen, Secretary General of the DGN.
The information, according to virus infections as a trigger of a brain inflammation/inflammation of the Brain (Meningitis/encephalitis) skin, per se, is not rare, the DGN has published in 2018, an S1 guideline. The present case report shows that there is also a SARS-CoV2-Meningitis.
The doctor suspected a flu
The DGN, according to reports in the currently published casuistry, that the affected 24-year-old man had visited in the first eight days of his illness because of fatigue, headache, Nausea, and fever is twice a doctor.
The doctors had suspected a flu and a influenza drug (Laninamivir), as well as fever-lowering drugs prescribed. A lung x-ray examination was unremarkable. According to the report, the young man was found dead on the ninth day of the disease of the family unconscious.
During the Ambulance transport, it came to several epileptic seizures, so that he had to be intubated and ventilated. In the hospital a pronounced neck was diagnosed stiffness, a main symptom of a brain skin inflammation (Meningitis).
The imaging investigation with MRI showed the finding of meningoencephalitis (meningeal and brain inflammation) with Hyper-intensities along the right lateral ventricular wall and the right mesiotemporal and hippocampal region.
In the chest CT evidence of viral pneumonia (lung inflammation) were found in addition. However, the nasopharyngeal swab for SARS-CoV-2 was negative in the CSF (cerebrospinal fluid) but specific to the SARS-CoV-2 RNA could be detected. The diagnostic work-up for other Meningitis-causing viruses according to DGN is negative.
“Not a purely pneumo-logical disease”
“The special feature of this case is that the virus detection in the CSF was positive, but not in the nose-throat swab. This indicates that the novel Coronavirus has spread here, obviously, via the neural route of infection,“ says Berlit.
The neural route of infection could in animal experiments with other corona viruses are already proven. The viruses are passed from Neuron to Neuron via the synapses. The casuistry deliver a proof that could spread SARS-CoV2 also in humans via this route of infection.
Also an Italian neurologist from Milan, virtually at the epicenter of the pandemic in Europe, reported in the journal “Neurology” that some COVID-19-patients had primarily neurological symptoms – it therefore recommends that every patient who presents with neurological symptoms, to test routinely for the SARS-CoV2.
“The new data, the evidence that Covid-19 is not a purely pneumo-logical disease,” says Berlit condense. “Also in neurological keynotes must be thinking of the novel pathogen.” (ad)