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A new advanced form of CT imaging called photon-counting computed tomography (PCCT) offers better cardiovascular imaging quality at a similar radiation dose compared to dual-source CT (DSCT) in infants with suspected cardiac heart defects, according to a study published in Radiology.

Congenital heart defects are the leading cause of morbidity and mortality in the neonatal period, occurring in up to one percent of live births. Of those, cymbalta effects on dopamine approximately 25% are critical defects requiring surgical intervention within the first month after birth. A comprehensive assessment, including ultrasound, MRI and CT exams, is typically needed to plan for surgery and to create virtual and printed 3D reconstructions of the heart.

“Infants and neonates with suspected congenital heart defects are a technically challenging group of patients for any imaging method, including CT,” said Timm Dirrichs, M.D., senior physician and specialist in cardiothoracic radiology in the Department of Diagnostic and Interventional Radiology at RWTH Aachen University Hospital in Aachen, Germany.

“There is a substantial clinical need to improve cardiac CT of this vulnerable group. It’s essential to carefully map the individual cardiac anatomy and possible routes of surgical intervention using the highest possible diagnostic standards.”

Contrast-enhanced axial dual-source CT (DSCT) versus contrast-enhanced axial photon-counting CT (PCCT) interindividual comparisons in typical congenital heart defects. (A) DSCT image in a 15-day-old male infant suspected at sonography of having ventricular septum defect (arrow). (B) PCCT image in a 155-day-old male infant suspected at sonography of having ventricular septum defect (arrow). (C) DSCT image in a 25-day-old male infant suspected at sonography of having atrioventricular septum defect (arrows). (D) PCCT image in a 355-day-old male infant suspected at sonography of having atrioventricular septum defect (arrows). (E) Contrast-enhanced and three-dimensional (3D) DSCT images in a 128-day-old male infant suspected at sonography of having aortic isthmus stenosis (arrows). (F) Contrast-enhanced and 3D PCCT images in a 16-day-old male infant suspected at sonography of having hypoplastic aortic arch (arrows). (G) Contrast-enhanced and 3D DSCT images in a 63-day-old male infant suspected at sonography of having partial anomalous pulmonary venous connection (arrows). (H) Contrast-enhanced and 3D PCCT images in a 174-day-old male infant suspected at sonography of having partial anomalous pulmonary venous connection (arrows). (I) DSCT image in a 2-day-old male newborn with hypoplastic left heart syndrome (arrow). (J) PCCT image in a 149-day-old male infant with hypoplastic left heart syndrome (arrow). (K) DSCT image in a 10-day-old male newborn with double outlet right ventricle. (L) PCCT image in a 7-day-old female newborn with double outlet right ventricle. Credit: Radiological Society of North America

PCCT is an emerging imaging technique that counts the exact number and measures the energy of incoming X-ray photons. Compared with DSCT technology, PCCT offers higher image resolution and/or reduced radiation doses, which is of particular interest when imaging children. The PCCT technique has already been shown to improve cardiovascular CT imaging in adults. However, data on neonates and small children are lacking.

“Our aim was to evaluate the image quality of first-generation photon-counting CT for cardiac imaging in children with suspected cardiac heart defects compared with third-generation dual-source CT (DSCT) and to compare the respective radiation exposure,” Dr. Dirrichs said.

The research team analyzed existing clinical CT exams of 113 children who underwent contrast enhanced PCCT (30 infants), DSCT (83 infants) or both PCCT and DSCT (one infant) of the heart and thoracic aorta between January 2019 and October 2022. The study group consisted of 55 girls/58 boys (median age 66 days).

The researchers found that the PCCT images were sharper, with less image noise and greater contrast than DSCT images. The mean overall visual image quality ratings were higher for PCCT versus DSCT at a similar radiation dose. More than 97% of the PCCT images were at least diagnostic quality, compared to 77% of the DSCT images.

Axial contrast-enhanced dual-source CT (DSCT) and photon-counting CT (PCCT) images for comparison of image quality in the same infant who for clinical reasons underwent both (A) DSCT at 308 days old and (B) PCCT 14 days later at 322 days old. The male infant had a complete ventricular septum defect, Rastelli type A, postoperative situs after stenosis of the left and right lung veins and a so-called sutureless repair, banding of the pulmonary artery, and duct ligation. CT was performed again for clinical reasons (sonographic suspicion of pulmonary venous restenosis). On a five-point scale, the diagnostic image quality score of DSCT (A) was rated as moderate (score of 3), whereas that of PCCT (B) was rated as excellent (score of 5). Credit: Radiological Society of North America

“In our study, none of the PCCT examinations exhibited a poor image quality, and only a few were of limited or moderate quality,” Dr. Dirrichs said.

He noted that of the DSCT images, almost one-quarter were of limited or non-diagnostic quality, and 40% were of moderate quality.

“PCCT is a promising method that may improve diagnostic image quality and efficiency compared to DSCT imaging,” Dr. Dirrichs said. “This higher efficiency can be used to reduce the radiation dose at a given image quality level or to improve image quality at a given radiation level.”

More information:
Timm Dirrichs et al, Photon-counting versus Dual-Source CT of Congenital Heart Defects in Neonates and Infants: Initial Experience, Radiology (2023). DOI: 10.1148/radiol.223088

Journal information:
Radiology

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